Noticias
Los Doctores Cidón
Madrigal y Merino Martín obtienen el Premio Nacional de Medicina Biológica Con este galardón se da un importante avance contra la depresión Fecha de la noticia 22 Junio 2012/ |
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Nos complace comunicar que el Premio Nacional de Investigación en Medicina Natural ha sido otorgado al trabajo de investigación sobre el papel de la curcumina como ansiolítico en depresión y como promotor de neurogénesis en cultivos de progenitores neurales de la zona subventricular bajo excitotoxicidad’, parcialmente financiado por los Laboratorios Nutergia (ERGYCARE). El presente trabajo de investigación ha sido realizado por el Dr. José Luis Cidón Madrigal. Investigador y Profesor de la Universidad de Alcalá (Madrid), doctor en Medicina, Cirugía y Ciencias Biológicas, y el Dr. José Joaquín Merino Martín, Investigador ¨Ramón y Cajal¨. IdiPaz. Y doctor en Bioquímica y Biología Molecular por Universidad Complutense de Madrid (UCM) e investigador principa del proyecto.
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Premio Nacional de Investigación en Medicina Natural
Nos complace comunicar que el Premio Nacional de Investigación en Medicina Natural, entregado durante el XXXI CONGRESO DE LA ASOCIACION ESPAÑOLA DE MEDICOS NATURISTAS, fue otorgado al trabajo de investigación sobre el papel de la curcumina como ansiolítico en depresión y como promotor de neurogénesis en cultivos de progenitores neurales de la zona subventricular bajo excitotoxicidad’, parcialmente financiado por los Laboratorios Nutergia, y realizado por el Dr. José Luis Cidón Madrigal. Investigador y Profesor de la Universidad¡ de Alcalá (Madrid), doctor en Medicina, Cirugía y Ciencias Biológicas, y el Dr. José Joaquín Merino Martín, Investigador ¨Ramón y Cajal¨. IdiPaz. Y doctor en Bioquímica y Biología Molecular por Universidad Complutense de Madrid (UCM) a los que desde la Fundación Española de Medicina Estéticay Longevidad les enviamos nuestra felicitación y agradecimiento
Laboratorios Nutergia ha financiado parcialmente el trabajo de investigación (ERGYCARE)
Dr. Milan Fiala., received 2008 Alzheimer Award
Journal of Alzheimer's Disease annual award for outstanding contribution
Milan Fiala, M.D., received 2008 Alzheimer Award
Journal of Alzheimer's Disease annual award for outstanding contribution
Milan Fiala, MD, UCLA Orthopedic Hospital, has been chosen as the recipient of the 2008 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of his outstanding work, "Phagocytosis of amyloid-beta and inflammation: Two faces of innate immunity in Alzheimer’s disease" by M. Fiala, D.H. Cribbs, M. Rosenthal and G. Bernard (July 2007, JAD 11(4): 457-63). Each year the Associate Editors of the journal select an outstanding article from the previous year's volume for this prestigious award.
“I am very grateful for the recognition of our laboratory’s work by the Journal of Alzheimer’s Disease,” said Dr. Fiala. This award belongs to all of my collaborators as well.” Dr. Fiala’s work suggests that Alzheimer’s disease is a failure of the immune system to keep the brain clear from waste products of neuronal chemistries (the most important waste is called amyloid-beta, in particular “oligomeric” amyloid-beta in neurons). This concept of Alzheimer’s disease can be compared to uremia when kidneys fail to clear the uremic waste products of body chemistries. In the brain, clearance of waste is difficult because the transport mechanisms across the brain “firewall” (called the “blood-brain barrier”) are restricted. The immune cells have the ability to cross the firewall, clean amyloid-beta and protect neurons, but in patients with Alzheimer’s disease, these cells somehow lose the ability to keep neurons healthy. In
These immune cells may be over-doing the cleaning task and become inflamed, and then cause damage to the brain as they do to an inflamed joint. Fortunately, in parallel with these mechanistic discoveries, Dr. Fiala’s collaborative research is showing that the immune system of patients can be improved, at least in a test tube, using natural products, such as curcuminoids from turmeric. Therefore, Dr. Fiala is developing a blood test of immune eficiency (so-called “amyloid-beta stress test”) and new ways of immune treatment as an all-inclusive approach to Alzheimer’s disease detection and prevention.
“We hope that these discoveries will lead to an all-inclusive approach to Alzheimer’s disease — detection at an early stage and improvement of the immune system using immunostimulating therapies (e.g curcuminoids) or anti-inflammatory therapies (similar to those used in joint disorders) according to the state of the immune system.,” stated Dr. Fiala. Dr. Fiala is a Research Professor of Orthopaedic Surgery at UCLA, Los Angeles, California. He received his initial training at the University of Charles IV, Prague, Czechoslovaki and his MD degree at the University of Geneva, Switzerland. He obtained a MSc (Epidemiology) from Harvard School of Public Health. He pursued translational research in respiratory, herpes and retroviruses viruses at the University of Washington, the University of Pennsylvania and UCLA, and his work played key role in controlling infections of immunocompromised patients.
In the last decade, Dr. Fiala has developed a modification of the amyloid-beta hypothesis suggesting that the underlying problem of Alzheimer’s disease patients lies in the defectiveness of the innate immune system to clear amyloid-beta in the brain. Dr. Fiala’s laboratory is situated in the Orthopaedic Hospital Research Center and includes key UCLA collaborators: John Adams, MD; Martin Hewison, PhD; Philip T. Liu, PhD; Araceli Espinosa-Jeffrey, PhD; Mark J. Rosenthal, MD; John M. Ringman, MD; and research staff including many gifted students. External collaborators include John Cashman, PhD, HBRI, San Diego; Naoyuki Taniguchi, Osaka University; and Albert S. Lossinsky, New Jersey Neuroscience Institute, Edison, New Jersey. This annual award, generously sponsored by Elan Pharmaceuticals, will be presented to Dr. Fiala at the International Conference on Alzheimer’s Disease 2008 held in Chicago in July.